The Prevalence of the Mutation in Codon 249 of the P53 Gene in Patients with Hepatocellular Carcinoma (HCC) in Turkey
✍ Scribed by Filiz Türe Özdemir; Arzu Tiftikci; Seda Sancak; Fatih Eren; Veysel Tahan; Hakan Akın; Feyza Gündüz; Ala Eldeen Kedrah; Yücel Üstündağ; Erol Avşar; Nurdan Tözün; Osman Özdoğan
- Book ID
- 107574735
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 164 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1941-6628
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📜 SIMILAR VOLUMES
## Abstract In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the __p__53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and ge
Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1(AFB1)-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversia
To clarify the clinical significance of the mutation of p53 gene in hepatocellular carcinoma (HCC), 90 resected specimens from Japanese patients were assayed using a polymerase chain reaction-single strand conformation polymorphism (PCRSSCP) analysis. p53 mutations were detected in 25 cases (27.8%)