249serp53 mutation in the serum of black southern African patients with hepatocellular carcinoma
β Scribed by GERALD C KIMBI; MICHAEL C KEW; MIMI C YU; KAZUKO ARAKAWA; JOHN HODKINSON
- Book ID
- 108950404
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 76 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0815-9319
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π SIMILAR VOLUMES
## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and southβeast China. A selective mutation in __TP53__ (AGGβAGT at codon 249, ArgβSer) has been identified as a hotspot in HCCs from such areas,
The prevalence of variant alkaline phosphatase in the serum of 335 southern African blacks with hepatocellular carcinoma was determined using polyacrylamide gel electrophoresis. The isoenzyme was detected in 2% (seven of 335) of the patients: it could not be found in the serum of 300 matched, health
Hepatocellular carcinoma (HCC) is less common and occurs at a much older age in urban than in rural southern African Blacks. These differences may reflect differences in the etiology of the tumor in the two populations. The purpose of this study was to compare the hepatitis B virus (HBV) status of 1