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Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore

✍ Scribed by Shi, CY; Phang, TW; Lin, Y; Wee, A; Li, B; Lee, HP; Ong, CN


Book ID
109837139
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
788 KB
Volume
72
Category
Article
ISSN
0007-0920

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## Abstract In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the __p__53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and ge