𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts

✍ Scribed by Denissenko, Mikhail F; Koudriakova, Tatiana B; Smith, Leslie; O'Connor, Timothy R; Riggs, Arthur D; Pfeifer, Gerd P

Book ID
110061685
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
509 KB
Volume
17
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inactivation of the DNA repair gene O6-m
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
✍ Yu-Jing Zhang; Yu Chen; Habibul Ahsan; Ruth M. Lunn; Po-Huang Lee; Chien-Jen Che 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)