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Methylation in the p53 Promoter Is a Supplementary Route to Breast Carcinogenesis: Correlation between CpG Methylation in the p53 Promoter and the Mutation of the p53 Gene in the Progression from Ductal Carcinoma In Situ to Invasive Ductal Carcinoma

✍ Scribed by Kim, Sun Jung; Noh, Dong-Young; Park, In Ae; Choe, Kuk Jin; Yoo, Ook Joon; Kang, Han-Sung; Kang, Joo Hyun

Book ID: 109886349
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 702 KB
Volume: 81
Category: Article
ISSN: 0023-6837
DOI: 10.1038/labinvest.3780266

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)