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Hepatocellular Carcinoma p53 G>T Transversions at Codon 249: The Fingerprint of Aflatoxin Exposure?

✍ Scribed by Tamar Lasky and Laurence Magder


Book ID
124290792
Publisher
Environmental Health Information Service
Year
1997
Tongue
English
Weight
828 KB
Volume
105
Category
Article
ISSN
0091-6765

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## Abstract A mutation in the tumor suppressor __p53__ gene resulting in an Arg→Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. To determine the significance of this mutation in an in vivo exp