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p53 codon 249ser hot-spot mutation in HBV-negative hepatocellular carcinoma

โœ Scribed by Yap, E.P.H.; Cooper, K.; Maharaj, B.; Mcgee, J.O'D.

Book ID
121994521
Publisher
The Lancet
Year
1993
Tongue
English
Weight
165 KB
Volume
341
Category
Article
ISSN
0140-6736

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Different frequencies of p53 codon-249 h
Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-Su province of China
โœ Yasuhito Shimizu; Ji-Jiang Zhu; Fang Han; Takatoshi Ishikawa; Hideaki Oda ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 100 KB

Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1(AFB1)-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversia