(018) Detection of P53 249ser polymorphism and HBV in hepatocellular carcinoma patients from Darfur
โ Scribed by Mahmoud Salma; Badreldin Yousif; Hiba Salah
- Book ID
- 119184124
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 40 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1687-1979
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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and southโeast China. A selective mutation in __TP53__ (AGGโAGT at codon 249, ArgโSer) has been identified as a hotspot in HCCs from such areas,
## Abstract In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the __p__53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene Xโray repair crossโcomplementary group 1 (XRCC1) Arg399Gln may be related with AFB1โDNA adducts and ge