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249 Quantitative detection of 249SER TP53 mutations in plasma DNA and risk for hepatocellular carcinoma

Book ID
117373761
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
253 KB
Volume
42
Category
Article
ISSN
0168-8278

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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGGβ†’AGT at codon 249, Argβ†’Ser) has been identified as a hotspot in HCCs from such areas,