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249ser TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma

✍ Scribed by Kirk, Gregory D; Lesi, Olufunmilayo A; Mendy, Maimuna; Szymañska, Katarzyna; Whittle, Hilton; Goedert, James J; Hainaut, Pierre; Montesano, Ruggero


Book ID
110069778
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
218 KB
Volume
24
Category
Article
ISSN
0950-9232

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Ser-249TP53 mutation in tumour and plasm
✍ Katarzyna Szymańska; Olufunmilayo A. Lesi; Gregory D. Kirk; Omar Sam; Philippe T 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 240 KB

## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGG→AGT at codon 249, Arg→Ser) has been identified as a hotspot in HCCs from such areas,