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Mutations at codon 249 of p53 gene in human hepatocellular carcinomas from Tongan, China

✍ Scribed by Mengsu Yang; Hong Zhou; Richard Y.C Kong; W.F Fong; Li-qiang Ren; Xiang-hai Liao; Yufang Wang; Weijian Zhuang; Shanming Yang

Book ID: 114071342
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 114 KB
Volume: 381
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(97)00142-5

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## Abstract In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the __p__53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and ge