✦ LIBER ✦

p27KIP1phosphorylation by PKB/Akt leads to poor breast cancer prognosis

✍ Scribed by Robert B Clarke

Book ID: 120701090
Publisher: BioMed Central
Year: 2003
Tongue: English
Weight: 37 KB
Volume: 5
Category: Article
ISSN: 1465-5411
DOI: 10.1186/bcr596

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

PKB/Akt mediates cell-cycle progression

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

✍ Shin, Incheol; Yakes, F Michael; Rojo, Federico; Shin, Nah-Young; Bakin, Andrei 📂 Article 📅 2002 🏛 Nature Publishing Group 🌐 English ⚖ 826 KB

PKB/Akt mediates cell-cycle progression

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

✍ Shin, Incheol; Yakes, F Michael; Rojo, Federico; Shin, Nah-Young; Bakin, Andrei 📂 Article 📅 2002 🏛 Nature Publishing Group 🌐 English ⚖ 826 KB

We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor p27(kip1). Blockade of HER2/neu in tumor cells inhibits Akt kinase activity and upregulates nuclear levels of the CDK inhibitor (Kip1). Recombinant Akt and Akt precipitated from tumor cells phosphorylated wild-type p27 i

PTEN-INDEPENDENT ACTIVATION OF THE PKB/A

PTEN-INDEPENDENT ACTIVATION OF THE PKB/AKT PATHWAY IN RENAL CELL CANCER AND INACTIVATION OF P27KIP BY PHOSPHORYLATION AT T157

✍ J. Hennenlotter; A.S. Merseburger; P.A. Ohneseit; P. Simon; A. Stenzl; M. Kuczyk 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 58 KB

Cytoplasmic re-localization and inhibiti

Cytoplasmic re-localization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by Akt-mediated phosphorylation in breast cancer

📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 127 KB

Repression of SHP-1 expression by p53 le

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

✍ Montano, X 📂 Article 📅 2009 🏛 Nature Publishing Group 🌐 English ⚖ 738 KB

Reduced expression of p27Kip1 protein is

Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation

✍ Sehwan Han; Kyeongmee Park; Hong‐Yong Kim; Myung‐Soo Lee; Hong‐Joo Kim; Young‐Du 📂 Article 📅 1999 🏛 Springer US 🌐 English ⚖ 94 KB