PKB/Akt mediates cell-cycle progression
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Shin, Incheol; Yakes, F Michael; Rojo, Federico; Shin, Nah-Young; Bakin, Andrei
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Article
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2002
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Nature Publishing Group
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English
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We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor p27(kip1). Blockade of HER2/neu in tumor cells inhibits Akt kinase activity and upregulates nuclear levels of the CDK inhibitor (Kip1). Recombinant Akt and Akt precipitated from tumor cells phosphorylated wild-type p27 i