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PTEN-INDEPENDENT ACTIVATION OF THE PKB/AKT PATHWAY IN RENAL CELL CANCER AND INACTIVATION OF P27KIP BY PHOSPHORYLATION AT T157

โœ Scribed by J. Hennenlotter; A.S. Merseburger; P.A. Ohneseit; P. Simon; A. Stenzl; M. Kuczyk


Book ID
118647187
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
58 KB
Volume
5
Category
Article
ISSN
1569-9056

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PKB/Akt mediates cell-cycle progression
โœ Shin, Incheol; Yakes, F Michael; Rojo, Federico; Shin, Nah-Young; Bakin, Andrei ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 826 KB

We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor p27(kip1). Blockade of HER2/neu in tumor cells inhibits Akt kinase activity and upregulates nuclear levels of the CDK inhibitor (Kip1). Recombinant Akt and Akt precipitated from tumor cells phosphorylated wild-type p27 i