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Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27kip1 in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27kip1 Expression and Localization

โœ Scribed by Maria Letizia Motti; Daniela Califano; Giancarlo Troncone; Carmela De Marco; Ilenia Migliaccio; Emiliano Palmieri; Luciano Pezzullo; Lucio Palombini; Alfredo Fusco; Giuseppe Viglietto


Book ID
117021300
Publisher
American Society for Investigative Pathology
Year
2005
Tongue
English
Weight
972 KB
Volume
166
Category
Article
ISSN
0002-9440

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โœ Alessandro Sgambato; Carlo Ratto; Beatrice Faraglia; Marta Merico; Raffaele Ardi ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 139 KB ๐Ÿ‘ 2 views

The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder