p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells

Reduced expression and altered subcellul

Reduced expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27Kip1 in human colon cancer

✍ Alessandro Sgambato; Carlo Ratto; Beatrice Faraglia; Marta Merico; Raffaele Ardi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 2 views

The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder