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Cytoplasmic re-localization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by Akt-mediated phosphorylation in breast cancer


Book ID
117659490
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
127 KB
Volume
38
Category
Article
ISSN
0959-8049

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The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder