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Progesterone inhibits human breast cancer cell growth through transcriptional upregulation of the cyclin-dependent kinase inhibitor p27Kip1 gene

✍ Scribed by Florence Gizard; Romain Robillard; Philippe Gervois; Anne Faucompré; Françoise Révillion; Jean-Philippe Peyrat; W. Dean Hum; Bart Staels


Book ID
116465993
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
362 KB
Volume
579
Category
Article
ISSN
0014-5793

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## Abstract The p27^Kip1^ (p27) cyclin‐dependent kinase inhibitor and c‐Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of __p27__ (__CDKN1B__) gene transcription by Forkhead box O proteins such as FOXO3a leads to growth arrest and apoptosis. Previ