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p16INK4A genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas

✍ Scribed by Esther M. O'Regan; Mary E. Toner; Stephen P. Finn; Chun Yang Fan; Martina Ring; Bjorn Hagmar; Conrad Timon; Paul Smyth; Susanne Cahill; Richard Flavin; Orla M. Sheils; John J. O'Leary


Book ID
116534430
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
301 KB
Volume
39
Category
Article
ISSN
1532-8392

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## Abstract Inactivation of the __p16^INK4A^__ (__CDKN2A)__ gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. De