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P16/INK4a Downregulation Is A Possible Trigger for Human Papillomavirus-associated Metachronous Head and Neck Squamous Cell Carcinoma

✍ Scribed by Ota, Y.; Sudo, T.; Tsujino, K.; Iwae, S.; Ohbayashi, C.; Soejima, T.


Book ID
122440738
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
41 KB
Volume
81
Category
Article
ISSN
0360-3016

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## Abstract Inactivation of the __p16^INK4A^__ (__CDKN2A)__ gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. De