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The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma

✍ Scribed by Elzbieta Stankiewicz; David M Prowse; Elena Ktori; Jack Cuzick; Laurence Ambroisine; Xiaoxi Zhang; Sakunthala Kudahetti; Nicholas Watkin; Catherine Corbishley; Daniel M Berney


Book ID
108781019
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
549 KB
Volume
58
Category
Article
ISSN
0309-0167

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## Abstract Two pathways leading to vulvar squamous cell carcinoma (SCC) exist. The expression of proliferation‐ and cell‐cycle‐related biomarkers and the presence of high‐risk (hr) HPV might be helpful to distinguish the premalignancies in both pathways. Seventy‐five differentiated vulvar intra‐ep