The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
✍ Scribed by Elzbieta Stankiewicz; David M Prowse; Elena Ktori; Jack Cuzick; Laurence Ambroisine; Xiaoxi Zhang; Sakunthala Kudahetti; Nicholas Watkin; Catherine Corbishley; Daniel M Berney
- Book ID
- 108781019
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 549 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0309-0167
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## Abstract Two pathways leading to vulvar squamous cell carcinoma (SCC) exist. The expression of proliferation‐ and cell‐cycle‐related biomarkers and the presence of high‐risk (hr) HPV might be helpful to distinguish the premalignancies in both pathways. Seventy‐five differentiated vulvar intra‐ep
## RESULTS. DO7, an anti-p53 monoclonal antibody, showed p53 overexpression in 35 carcinomas (53%). Consensus primer PCR showed HPV infection in 12 carcinomas