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Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16INK4A overexpression and clinicopathological correlations

✍ Scribed by Victoria Fuste; Marta del Pino; Assumpta Perez; Angel Garcia; Aureli Torne; Jaume Pahisa; Jaume Ordi

Book ID: 108780991
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 859 KB
Volume: 57
Category: Article
ISSN: 0309-0167
DOI: 10.1111/j.1365-2559.2010.03727.x

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an