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Temporal inactivation of p16 (CDKN2, INK4A, MTS-1) tumor suppressor gene: Is p 16 the gatekeeper gene of head and neck squamous cell carcinoma?

✍ Scribed by Andre L. Reed; Joseph A. Califano III; William H. Westra; David Sidransky; Wayne Koch

Book ID
117402714
Publisher
SAGE Publications
Year
1997
Tongue
English
Weight
116 KB
Volume
117
Category
Article
ISSN
0194-5998

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✍ K Biden; J Young; R Buttenshaw; J Searle; G Cooksley; D B Xu; B Leggett πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 476 KB

The tumor suppressor gene CDKN2A (MTS1/p16), located on chromosome 9p21, is inactivated in a variety of tumors including melanomas and tumors of the biliary tract, pancreas, and stomach. The aim of the present study was to determine whether this gene is inactivated in hepatocellular carcinoma (HCC).