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Frequency of Genetic and Epigenetic Alterations of p14ARF and p16INK4A in Head and Neck Cancer in a Hungarian Population

✍ Scribed by Kis, Andrea; Tatár, Tímea Zsófia; Gáll, Tamás; Boda, Róbert; Tar, Ildikó; Major, Tamás; Redl, Pál; Gergely, Lajos; Szarka, Krisztina

Book ID
125379754
Publisher
Springer Netherlands
Year
2014
Tongue
English
Weight
190 KB
Volume
20
Category
Article
ISSN
1219-4956

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## Abstract Mantle cell lymphoma (MCL) is characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in overexpression of CCND1 in the vast majority of cases. In addition, alterations of other cell‐cycle‐regulating signal pathways (CDKN2B/CDKN2A‐CCND1 and ARF‐MDM2‐TP53) are frequen