P1-276: Search for mutations in early-onset Alzheimer’s disease
✍ Scribed by Anastasiya V. Kazantseva; Olga V. Plotnikova; Egor M. Veselovsky; Evgeny I. Rogaev
- Book ID
- 118462725
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 53 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1552-5260
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## Background: Early-onset familial alzheimer's disease (eofad) is linked to mutations in three autosomal dominant genes: ps1, ps2 and app. the clinical presentation and age of onset of mutations is variable. ## Objectives: The aim of this report is to describe a novel ps1 mutation believed to be
Familial Alzheimer's disease (AD) is an autosomal dominant disorder characterized by memory impairment and multiple cognitive deficits which occurs in mid to late life. Early onset AD has been associated with mutations in three genes, of which presenilin 1 (PS1) mutations are the most frequent. We s