## Background: Early-onset familial alzheimer's disease (eofad) is linked to mutations in three autosomal dominant genes: ps1, ps2 and app. the clinical presentation and age of onset of mutations is variable. ## Objectives: The aim of this report is to describe a novel ps1 mutation believed to be
โฆ LIBER โฆ
Splicing mutation of presenilin-1 gene for early-onset familial Alzheimer's disease
โ Scribed by Shinji Sato; Kouzin Kamino; Tetsuro Miki; Akira Doi; Kunio Ii; Peter H. St George-Hyslop; Toshio Ogihara; Yoshiyuki Sakaki
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 368 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1059-7794
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Mutations in the presenilin genes (PS-1 and PS-2) cause early onset autosomal dominant Alzheimer's disease (AD). Eight early-onset, autopsy-documented familial AD kindreds were screened for mutations in PS-1, and seven different mutations were identified. Three of these were new mutations (G209V, A4
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