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Optimization of 1,4-Diazepan-2-one-Containing Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type-2 Diabetes.

โœ Scribed by Gui-Bai Liang; et al. et al.


Publisher
John Wiley and Sons
Year
2007
Weight
24 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPPโ€IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).