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ChemInform Abstract: The Asymmetric Synthesis of Sitagliptin, a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes.

✍ Scribed by Feng Liu; Wansheng Yu; Wenhua Ou; Xiaoke Wang; Libo Ruan; Yiming Li; Xijiang Peng; Xiaohu Tao; Xianhua Pan

Publisher: John Wiley and Sons
Year: 2010
Weight: 23 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201041163

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✦ Synopsis

Abstract

Key step in the improved synthetic pathway to sitagliptin (VII), a new DPP‐IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).

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