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ChemInform Abstract: Discovery of Carmegliptin (I): A Potent and Long-Acting Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes.

✍ Scribed by Patrizio Mattei; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
16 KB
Volume
41
Category
Article
ISSN
0931-7597

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ChemInform Abstract: The Asymmetric Synt
✍ Feng Liu; Wansheng Yu; Wenhua Ou; Xiaoke Wang; Libo Ruan; Yiming Li; Xijiang Pen πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 23 KB

## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPP‐IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).