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ChemInform Abstract: Discovery of DA-1229 (I): A Potent, Long Acting Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes.

โœ Scribed by Bong Jin Lee; et al. et al.


Publisher
John Wiley and Sons
Year
2011
Weight
20 KB
Volume
42
Category
Article
ISSN
0931-7597

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## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPPโ€IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).