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Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH

โœ Scribed by Gagner, J.-P.; Drouin, J.

Book ID
122913094
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
592 KB
Volume
40
Category
Article
ISSN
0303-7207

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Pro-opiomelanocortin gene: A model for n
Pro-opiomelanocortin gene: A model for negative regulation of transcription by glucocorticoids
โœ Jacques Drouin; Jean Charron; Jean-Pierre Gagner; Lucie Jeannotte; Mona Nemer; R ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 858 KB

The gene encoding pro-opiomelanocortin (POMC) offers an interesting model system to study negative control of transcription in eucaryotes. Indeed, glucocorticoid hormones specifically inhibit transcription of the POMC gene in the anterior pituitary. The POMC gene is predominantly expressed in the an