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Regulation of pro-opiomelanocortin biosynthesis and processing by transplantation immunity

✍ Scribed by Zakarian, S.; Eleazar, M. S.; Silvers, W. K.


Book ID
109759181
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
430 KB
Volume
339
Category
Article
ISSN
0028-0836

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The gene encoding pro-opiomelanocortin (POMC) offers an interesting model system to study negative control of transcription in eucaryotes. Indeed, glucocorticoid hormones specifically inhibit transcription of the POMC gene in the anterior pituitary. The POMC gene is predominantly expressed in the an