Novel Stereoselective Synthesis of 4-Acetoxyazetidinone from Methyl 6,6-Dibromopenicillanate: Key Intermediate for the Preparation of Carbapenem Antibiotics
โ Scribed by Long, Bohua; Xiang, Jiannan
- Book ID
- 120193646
- Publisher
- Taylor and Francis Group
- Year
- 2009
- Tongue
- English
- Weight
- 191 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0039-7911
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๐ SIMILAR VOLUMES
The stereoselective synthesis of a protected 4-fonnyltrinem 8 was accomplished in good yield. This connpound is a I~tenlial intermediate in the synthesis of a wide range of 4-alkyl and alkenyl substituted trineua antibiotics, as evidenced by its reaction with a series of phosphoranes and phosphonatc
A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active โค-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.