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A short, stereoselective synthesis of (3R,4R)-4-acetoxy-3-[(R)-1′((t-butyldimethylsilyl)oxy) ethyl]-2-azetidinone, key intermediate for the preparation of carbapenem antibiotics

✍ Scribed by Franco Cozzi; Rita Annunziata; Mauro Cinquini; Laura Poletti; Alcide Perboni; Bruno Tamburini

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
63 KB
Volume
10
Category
Article
ISSN
0899-0042

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✦ Synopsis

A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active ␤-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.

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