Preparative Synthesis of the Key Intermediate, (4R,5R)-3-Benzyloxymethyl-4,5-isopropylidenedioxycyclopent-2-enone for Carbocyclic Nucleosides.
β Scribed by Hyung Ryong Moon; Won Jun Choi; Hea Ok Kim; Lak Shin Jeong
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 30 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active β€-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.
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## Reinvestigation of the Synthesis of (2R,3R) 2,3-(Cyclohexylidenedioxy)-4-cyclopentenone as Possible Building Block for the Synthesis of Carbocyclic Nucleosides. -An in depth study of the four-step synthesis of the title compound ( VIII) is described. The reactions are reinvestigated, by-produc