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ChemInform Abstract: A Practical Synthesis of 3-[(1R)-1-t-Butyldimethylsilyloxyethyl]-4- [(2R)-4-halo-3-oxo-2-butyl]azetidinone, a Versatile Intermediate for Carbapenem Antibiotics.

โœ Scribed by C. YANG; N. YASUDA

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

A Practical Synthesis of 3-[(1R)-1-t-Butyldimethylsilyloxyethyl]-4-[(2R)-4-halo-3-oxo-2-butyl]azetidinone, a Versatile Intermediate for Carbapenem Antibiotics.

-The readily available carboxylic acid (I) is converted efficiently by a three-step procedure into the title compounds such as (VI). Desilylation is prevented using a nonaqueous quench with anhydrous acetic acid.

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