ChemInform Abstract: Enantio- and Diastereoselective Synthesis of N-[(1R,2R,3R,4R)-2,3-Diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide, a Synthetic Key Intermediate of (+)-Cyclaradine.
β Scribed by Y. NORIMINE; M. HAYASHI; M. TANAKA; H. SUEMUNE
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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A Convenient Stereoselective Synthesis of (1R,2S,3R,4S)-3-(Neopentyloxy)isoborneol. -The first regio-and stereoselective synthesis of the title compound (VI), a valuable chiral auxiliary, is developed starting from the camphorquinone (I) in six steps and 48% overall yield. -