The Stereoselective Synthesis of 4-Formyltrinem, a Key Intermediate for Novel Trinems. -Title compound (VIII) is a key intermediate for the preparation of a wide range of trinem derivatives. This is demonstrated by performing some Wittig reactions.
ChemInform Abstract: Novel Stereoselective Synthesis of 4-Acetoxyazetidinone from Methyl 6,6-Dibromopenicillanate: Key Intermediate for the Preparation of Carbapenem Antibiotics.
β Scribed by Bohua Long; Jiannan Xiang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 46 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active β€-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.
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