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Novel polymorphism in p21waf1/cip1 cyclin dependent kinase inhibitor gene: association with human esophageal cancer

โœ Scribed by Bahl, Rimple; Arora, Sonia; Nath, Neera; Mathur, Meera; Shukla, Nootan K; Ralhan, Ranju

Book ID
110062678
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
502 KB
Volume
19
Category
Article
ISSN
0950-9232

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet