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Identification of aPstI polymorphism in the p21Cip1/Waf1cyclin-dependent kinase inhibitor gene

โœ Scribed by John C. Law; Anee Deka

Publisher
Springer
Year
1995
Tongue
English
Weight
216 KB
Volume
95
Category
Article
ISSN
0340-6717

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet

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in signaling cellular growth arrest. In response to DNA damage, p21 is induced by the p53 gene, thereby playing a direct role in mediating p53-induced G 1 arrest.