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Osteoclast differentiation is associated with transient upregulation of cyclin-dependent kinase inhibitors p21WAF1/CIP1 and p27KIP1

✍ Scribed by Nobuo Okahashi; Yoshiyuki Murase; Takeyoshi Koseki; Tsuyoshi Sato; Kenji Yamato; Tatsuji Nishihara


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
194 KB
Volume
80
Category
Article
ISSN
0730-2312

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Reduced expression of the cyclin-dependent kinase inhibitor p27 Kip1 has been reported to correlate with poor survival in cohorts of breast and colorectal carcinoma patients. Posttranslational ubiquitin-mediated proteasomal proteolysis is related to p27 Kip1 protein levels. However, to the authors'