p21 WAF1/Cip1 is an inhibitor of cdk/cyclin complexes, and thus regulates the cell cycle. p21 is also related to cell differentiation and is regulated by wild-type p53, although p53-independent regulatory pathways have been proposed. In order to analyse p21 expression as well as its relationship wit
Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival
β Scribed by Tracey A. Holland; Jackie Elder; Jonathan M. McCloud; Christine Hall; Mark Deakin; Anthony A. Fryer; James B. Elder; Paul R. Hoban
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 423 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0020-7136
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## RESULTS. Various levels of p21 and p53 immunoreactivities in carcinoma cells were detected in 30 (32%) and 60 (65%), respectively, of 93 samples. There was no 1 First Department of Pathology, Faculty of Medcorrelation between p21 and p53 expression. The 5-year survival rate of patients icine, T
Background and Objectives: p27Kip1 is an inhibitor of cyclindependent kinases and is speculated to be a potential prognostic indicator in numerous human cancers. We investigated expression of p27Kip1 along with cyclin D1 in gastric cancer to estimate the clinical utility of p27Kip1. Methods: Immunoh