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A cyclin-dependent kinase inhibitor (p21WAF1/CIP1) affects thymidine incorporation in human liver cancer cells

โœ Scribed by Gong, Y; Deng, S; Zhang, M; Wang, G; Minuk, G Y; Burczynski, F

Book ID
109997137
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
145 KB
Volume
86
Category
Article
ISSN
0007-0920

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet