Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic depsipeptide from the cyanobacterium Nostoc sp.
โ Scribed by Kunimitsu Kaya; Tomoharu Sano; Kenneth A. Beattie; Geoffrey A. Codd
- Book ID
- 104255743
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 189 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic peptide was isolated from a hepatotoxic strain of cyanobacterium Nostoc sp. Nostocyclin is non-toxic in acute in vivo bioassays, but inhibits protein phosphatase-1 activity at high concentration in vitro.
๐ SIMILAR VOLUMES
The synthetic studies of micropeptin T-20 including the late installation of the Ahp (3-amino-6-hydroxy-2-piperidone) residue through oxidation and cyclization of a homoserine to the requisite hemiaminal are described.
The first total synthesis of somamide A (1), an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide, from the marine cyanobacterium Lyngbya majuscula is described. The efficient and stereospecific dehydration of the N-acyl threonine ester using Martin's sulfurane provided the (Z)-2-a