Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide
โ Scribed by Fumiaki Yokokawa; Akiko Inaizumi; Takayuki Shioiri
- Book ID
- 104231197
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 105 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The synthetic studies of micropeptin T-20 including the late installation of the Ahp (3-amino-6-hydroxy-2-piperidone) residue through oxidation and cyclization of a homoserine to the requisite hemiaminal are described.
๐ SIMILAR VOLUMES
The first total synthesis of somamide A (1), an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide, from the marine cyanobacterium Lyngbya majuscula is described. The efficient and stereospecific dehydration of the N-acyl threonine ester using Martin's sulfurane provided the (Z)-2-a
Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic peptide was isolated from a hepatotoxic strain of cyanobacterium Nostoc sp. Nostocyclin is non-toxic in acute in vivo bioassays, but inhibits protein phosphatase-1 activity at high concentration in vitro.