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Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

โœ Scribed by Kazuo Umezawa; Kumi Nakazawa; Toshio Uemura; Yoko Ikeda; Shinichi Kondo; Hiroshi Naganawa; Naoko Kinoshita; Hideki Hashizume; Masa Hamada; Tomio Takeuchi; Shigeru Ohba

Book ID
108386561
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
268 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœ Kunimitsu Kaya; Tomoharu Sano; Kenneth A. Beattie; Geoffrey A. Codd ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 189 KB

Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic peptide was isolated from a hepatotoxic strain of cyanobacterium Nostoc sp. Nostocyclin is non-toxic in acute in vivo bioassays, but inhibits protein phosphatase-1 activity at high concentration in vitro.