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New light on multidrug binding by an ATP-binding-cassette transporter

✍ Scribed by Richard A. Shilling; Henrietta Venter; Saroj Velamakanni; Akanksha Bapna; Barbara Woebking; Sanjay Shahi; Hendrik W. van Veen

Book ID
116918613
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
432 KB
Volume
27
Category
Article
ISSN
0165-6147

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Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s