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Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters

✍ Scribed by Sorbo, G. Del ;Andrade, A. C. ;Nistelrooy, J. G. M. Van ;Kan, J. A. L. Van ;Balzi, E. ;Waard, M. A. De


Publisher
Springer
Year
1997
Tongue
English
Weight
401 KB
Volume
254
Category
Article
ISSN
0026-8925

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Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s