Multidrug resistance mediated by the ATP
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Susan P.C. Cole; Roger G. Deeley
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Article
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1998
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John Wiley and Sons
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English
β 203 KB
Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s