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Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism

โœ Scribed by Hendrik W van Veen; Christopher F Higgins; Wil N Konings


Book ID
117615142
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
228 KB
Volume
152
Category
Article
ISSN
0923-2508

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Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s