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New founding mutation in MSH2 associated with hereditary nonpolyposis colorectal cancer syndrome on the Island of Tenerife

✍ Scribed by Vicente Medina-Arana; Ysamar Barrios; Antonia Fernández-Peralta; Mercedes Herrera; Nancy Chinea; Nieves Lorenzo; Alejandro Jiménez; Juana Victoria Martín-López; Fernando González-Hermoso; Eduardo Salido; Juan J. González-Aguilera

Book ID
116334117
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
216 KB
Volume
244
Category
Article
ISSN
0304-3835

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✍ Alessandra Viel; Maurizio Genuardi; Eugenia Capozzi; Francesca Leonardi; Alfonso 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB 👁 2 views

Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred